After retiring from Werewolf hunting, Neon Joe manages Oahu Joe's, a tropical-themed bar. When Neon Joe gets an unexpected visitor from his past, he must resist the temptation to give into his anger.

Neon Joe is sentenced to prison for a crime he didn't commit, the murder of Plaid Jeff.

After escaping from prison, Neon Joe finds his way to Vance Dontay while being pursued by Jewish skinheads and the FBI.

Neon Joe and Vance Dontay make a determined effort to set aside their differences for the greater good, saving the planet Earth.

After reconciling, Neon Joe and Vance Dontay must team up with Plaid Jeff to save the world from The Cube.