- | 4 Episodes

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2014 | 11 Episodes

Season 1 of The Cyanide & Happiness Show premiered on November 12, 2014.

2015 | 10 Episodes

Season 2 of The Cyanide & Happiness Show premiered on December 9, 2015.

2017 | 10 Episodes

Season 3 of The Cyanide & Happiness Show premiered on February 2, 2017.

2019 | 10 Episodes

Season 4 of The Cyanide & Happiness Show premiered on September 18, 2019.