In Mr. Pickles, the urban sprawl of modern society pollutes the old-fashioned town where the Goodman family lives with their lovable pet dog, Mr. Pickles, a deviant collie with a secret satanic streak.

After Mr. Pickles framed Grandpa for murder in the Season 3 finale, Sheriff learns of Grandpa's whereabouts, and heads out of the country to track him down. Meanwhile Grandpa has a new determination to finally end things with Mr. Pickles.