This season takes The Real World across the border into Cancun, Mexico. Eight new strangers move into their ME Suite in Cancun, Mexico and get to know each other. CJ seems to be the heartthrob of the house, but after snuggling with Emilee, his previous relationship comes to an end. Joey is quick to sow his wild Cancun oats and hooks up with a local girl while Bronne makes out with the girls mom

Jonna and CJ find themselves getting close, whereas Ayiiia and Joey's feud continues. Also, the roommates meet up with their new boss and are told what job they will be doing.

Things between Ayiiia and Emilee heats up. Meanwhile, the guys vent over their frustrations concerning Ayiiia.

Jasmine has her eyes set on Pat, a StudentCity boss; and Derek receives a visit to the Cancun house by his ex.

Tension within the Cancun house has reached an all-time high when Joey attempts to send Ayiiia home.

One roommates job and stay in Cancun may be in jeopardy due to irresponsible behavior. Also, Jonna receives a visit from her boyfriend.

When she is rejected by Pat, a devastated Jasmine turns to alcohol to cope with her emotions as Jonna and Pat get closer. The roommates raise money to help DIF, a local Cancun children's charity.

Jasmine hooks up with Pat's cousin, JR, which drives Jonna and Pat closer together and Jonna breaks up with Matt. Also, Bronne's antics get him banished from the ME hotel.

Ayiiia begins to miss her boyfriend Ryan and sets her sights on Jonna, which ends in a threesome between Pat, Jonna, and Ayiiia. Tension rises between Jonna and Emilee over Jonna keeping the threesome a secret from her.

One cast member has been sent to jail. Emilee incurs Bronne's wrath after destroying his prized magazines.

Season 22 ends as the roommates say their good-byes and leave Cancun.