Haunted by the failure to catch London's most evil killer, Jack the Ripper, Inspector Edmund Reid now heads up the notorious H Division - the toughest police district in the East End.

The memory of Jack the Ripper may have faded but the Whitechapel streets he walked are more dangerous than ever.

After a locomotive disaster, Reid's iron grip on 'H' Division begins to unravel.

In 1897, Reid has given up his detective work and lives in Hampton-on-Sea with Matilda. When his old friend Isaac is accused of murder, he is drawn back to Whitechapel to investigate. Meanwhile Drake is now head inspector of Whitechapel and still employs Jackson who has given up his drinking and gambling in order to save money to free Susan from prison.

Returning to a dark secret they all share and to a Whitechapel terrorised by an all too familiar horror, Series Five sees the show’s heroes take on a serial killer with subhuman desires, but a superhuman ability to avoid being apprehended.