At The Kingdom, Denmark's most technologically advanced hospital, a number of strange and otherworldly events begin occurring, much to the dismay of its doctors and patients. A ghostly ambulance appears and disappears, the voice of a little girl calls to a patient in an elevator shaft, and a doctor's fetus begins growing at an alarming rate.

The mutant fetus is born. Dr. Helmer comes under heavy scrutiny for a botched operation that left a patient braindead, and begins to dabble in the dark arts in order to ward off those seeking an end to his career. Hypochondriac Mrs. Drusse finally does have something bad happen to her medically when an ambulance hits her.

Sleepwalker Karen is summoned to the Kingdom by a mysterious voice appearing to her in a nightmare, pleading for help. At the hospital, she comes across old friends of the Kingdom as well as new members of staff. To exorcise the evil spirits once and for all, Karen joins forces with the hospital porter, Bulder, and the heart surgeon, Judith – but satanic forces fight back.