About a year has passed in the lives of the Cesaroni family and their friends from Garbatella: Marco and Eva have just returned from the X Tour with little Marta, who is everyone's joy. Rudi, Alice, Budino, Jolanda, Lorenzo, and Regina return from vacation, struggling with adolescence. And Carlotta also rejoins Eva and Walter's lives.

After two weeks of heated discussions and arguments, the crisis between Giulio and Lucia hasn't subsided. The two have decided to separate. Giulio acts calm, but it's just a facade. He begins to have a crisis and decides to seek therapy from Emma, the sister of Olga, the wedding planner for Cesare's wedding. Things are also getting tough for Ezio: he argues with Walter, who wanted to repair a motorcycle at the shop.

Giulio, in the midst of therapy, is still suffering. Furthermore, he believes Ezio and Cesare are ignoring him, but they are only doing so for his own good. After going to Venice with her mother, Alice returns to start school again. At class, Rudi meets a new student: Miriam, Olga's daughter. Mimmo also meets Andy, the wedding planner's other son.

Marco and Eva, who have decided to stay at the Cesaroni house to help Giulio, are unable to sleep because of Marta's crying, as she's teething. Alice, on the other hand, has met a wonderful boy and would like to make love to him, but she's not ready yet. Walter, who had lent her the house, is relieved.

Giulio's moment of truth has arrived with Lucia. A new traffic cop is terrifying everyone in Garbatella: it's Germana. She's decided to return to her job after Barilon's shop goes into crisis. Ezio and Cesare decide to sabotage her, but something goes wrong. Ezio can't sell the shop, but Barilon has the right idea, and the two become partners.

After meeting Lucia, Giulio is officially separated and out of therapy. He decides to celebrate by going camping with Ezio and Cesare, but Barilon, feeling left out, plans to sabotage his outing. Gabriella, who blames Giulio for the end of her marriage to Lucia, never sets foot in the Cesaroni household again, but she misses everyone and pretends to be ill to have them around again.

After the trip to Misano, Walter and Alice have grown closer, but both are afraid to declare their feelings for the consequences it would have on their respective families. Only Palmiro, the old mechanic at the garage, urges Walter to take the plunge, and it is Palmiro who, tragically, brings the two together.

Since Giulio has been single, he's always on edge. Ezio and Cesare realize he needs to get back on track. The three embark on a series of tragicomic attempts to meet women. When all seems lost, Giulio meets Gianna. Ezio and Cesare have a hand in it, but have they made the right choice?

Alice and Walter live their relationship in secret. Marco and Eva both work in radio and don't have much time for themselves anymore. Giulio and Olga have a connection, but Olga can't take it any further. Olga takes advantage of the situation to organize the launch of her sister Emma's book at the wine shop, but her ideas for renovating the place cause a clash between Giulio and Cesare.

Since he's been seeing Olga, Giulio has been constantly away from home, attending exhibitions and events she organizes. Stefania and Pamela urge their husbands to be less of a couch potato. Ezio and Cesare then infiltrate an exclusive party Olga is hosting at a golf club, resulting in a series of hilarious incidents and misunderstandings.

Giulio is furious with Walter and Alice and their secret affair. So are Ezio and Stefania. Marco and Eva, on the other hand, are disappointed: they expected more honesty from their best friend and sister. Furthermore, Walter, under the stress, breaks a key part of the motorcycle he was modifying.

The fire at the garage and motorcycle throws Walter into a panic. Walter is drawn dangerously into the world of horse racing. Luckily, this is the right time for Ezio to bury the hatchet and act like a father. Olga and her children have a problem at home and turn to Giulio for help.

Marco and Eva don't know who to trust with Marta: Alice is on a trip with Rudi and the others, Gabriella is away, and Giulio is always out with Olga. Ezio and Cesare step forward: however, the two decide to enter the girl in a competition at Cinecittà, encountering a series of comical complications that spiral into tragedy when they lose the child.

Marco and Eva, after the shock of Marta's disappearance, realize they've spent too much time at work and too little time with their family. They decide to treat themselves to a relaxing day at the beach. But Marco has a secret that's making him feel bad, and it will come out, upsetting his relationship with Eva. Walter and Carlotta also face a moment of truth: they love each other. She leaves her husband, and he leaves Alice, who, however, doesn't know about Carlotta.

Olga finally makes herself heard, but she has no intention of returning. She entrusts the children to Emma, with Giulio willing to keep them at his house. Furthermore, the two, aided by Ezio and Cesare, must cope with a birthday party Olga was supposed to organize, which will have unpredictable outcomes. Marco is devastated: Eva has gone with Marta to Venice to visit Lucia.

Marco gets a setback from his record company: his album isn't well received. He spirals into self-destruction. Alice is heartbroken over the end of her relationship with Walter. To cheer her up, Jolanda throws her a party, which, however, goes haywire.

No one is willing to play in the traditional match against the San Paolo neighborhood: neither Marco, who is increasingly depressed, nor Lorenzo, who is busy trying out for a professional team. Ezio, Giulio, and Cesare, convinced they'll win anyway, are forced to enlist some of the girls, including Regina, Jolanda, and Miriam.

Emma is scheduled to attend a conference on stalking, and Ezio and Cesare become convinced that she's being stalked by a maniac. The man is actually Flavio, Emma's ex, who has resurfaced. Giulio helps the therapist win him back, but is their closeness merely friendship?

Stefania and Giulio offer to host two Argentine students for a few days: David, whose good looks upset the principal, and Pedro. Miriam tries everything she can to lure Alice into David's arms, just to keep her away from Rudi. Emma, after dismissing Flavio, admits to Stefania that she's in love with Giulio, but the relationship scares her and threatens to jeopardize her therapy with a patient who's threatening suicide.

Olga has returned profoundly changed. Still in love with Giulio, she intends to win him back, but she hasn't reckoned with Emma, who has finally decided to reveal her feelings. Giulio is caught between two fires, and the surprises aren't over. Ezio is deeply hurt by Stefania's betrayal and has no intention of forgiving her.