Season 1 of Room 222 premiered on September 17, 1969.

Season 2 of Room 222 premiered on September 23, 1970.

Season 3 of Room 222 premiered on September 17, 1971.

Season 4 of Room 222 premiered on September 15, 1972.

Season 5 of Room 222 premiered on September 14, 1973.