- | 4 Episodes

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2006 | 23 Episodes

Season 1 of Brothers and Sisters premiered on September 24, 2006.

2007 | 16 Episodes

Season 2 of Brothers and Sisters premiered on September 30, 2007.

2008 | 24 Episodes

Season 3 of Brothers and Sisters premiered on September 28, 2008.

2009 | 24 Episodes

Season 4 of Brothers and Sisters premiered on September 27, 2009.

2010 | 22 Episodes

Season 5 of Brothers and Sisters premiered on September 26, 2010.