Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. At university, Maria meets Guido, a brilliant doctor who is looking for a place to live and will be hired by the new director of the local health authority. Maria is fascinated by Guido, but the doctor seems completely uninterested in her. Meanwhile, Ciccio, after a prank that nearly ended in tragedy, attempts to escape from Lele in Australia.

Enrica notices the growing connection between Maria and Guido and puts a "flea in Grandpa Libero's ear," who begins to worry. Meanwhile, everyone begins to discover that Alberto hasn't even passed a single university exam. Grandpa Libero doesn't want anything to happen between Guido and Maria and does everything he can to keep them apart. Meanwhile, Alberto is depressed and sleeps in the garage to be alone. It will take his family's help to pull him out of this dark depression.

Cettina sets out to find Giacinto, discovering a bitter truth. Maria, due to a painful experience, no longer wants to take her medical tests. Will Guido be able to convince her otherwise? Nilde is forced to close the restaurant due to a poisoning and notices that Guido is the one signing the complaint. Alberto, improvising a late-night radio show, manages to get a permanent job.

A new nutritionist, Carlotta, arrives at the local health authority. Her obsessive and aloof behavior fails to win her affection, and misunderstandings and disagreements arise between her and Guido. Until something brings them together again.

Guido tries to befriend Carlotta, but the obstacle he has to overcome is her phobia of physical contact, a difficult obstacle to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Grandpa Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too quiet, and Antoinette doesn't understand why, so Grandpa Libero invites her to take him to the local health authority so Guido can examine him. A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation quickly escalates, verging on disaster.

Carlotta confesses to Guido that she's in love with him, sending him into a crisis because he can't understand his feelings for Maria. Their birthday dinner, however, is cancelled due to an unexpected event. Maria is delighted to have met Gianluca, a charming lawyer who courts her like a true princess. Meanwhile, at Ciccio's school, some kids break in at night and break the pipes to skip tests and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, bearing a flag with the word "Maria" written on it. Meanwhile, Guido has started dating Carlotta, and everything seems to be going well... or not? Carlotta suggests that Guido move in together, and the doctor accepts. Meanwhile, Maria, having broken off her relationship with Gianluca, has begun volunteering at a drug rehabilitation center.

Maria is preparing for an exam and is very nervous, and Grandpa Libero thinks it's Gianluca's fault. Guido and Carlotta continue their relationship, even though the breakup puts a strain on their relationship. Grandpa Libero hears the news on the news that a young blonde student has been arrested in Fiumicino along with Gianluca for drug dealing. Thinking it's Maria, he feels ill and suffers a heart attack.

Meanwhile, Guido is having problems with Carlotta, who's fed up with seeing her boyfriend completely absorbed in the Martini family. Maria sees Gianluca in front of her house, telling her he wants to run away to avoid the trial. Guido and Carlotta are increasingly at odds, and they argue again during dinner. Guido goes to a friend's house, who introduces him to two girls, and the next morning, the doctor wakes up drunk next to one of them.

Maria is angry with Guido and disappointed because he cheated on Carlotta. A self-esteem course is being held at the local health authority, and thanks to it, the doctors are able to talk about their problems, especially Carlotta's. Guido and Maria go to pick up Annuccia at the zoo, but the little girl gets lost. Because of this, Guido doesn't show up for his appointment with Carlotta, but in the meantime, Maria and the doctor finally kiss.

After their kiss at the zoo, Guido realizes he has strong feelings for Maria, but she wants him to leave Carlotta first. Meanwhile, Carlotta seems increasingly attached to Marcello, and not just for work. Maria is tired of waiting for Guido and decides to go out and distract herself with Reby. During a night out, she's stopped by the police and her car is confiscated. Who will get her out of this mess?

Maria and Guido go to the beach to be alone, and when they return home, covered in sand, Libero realizes they spent the afternoon together. Due to a mistake, Guido is suspended from the local health authority. Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that everyone already knew. Meanwhile, Guido makes house calls, and patients show up at the Martini house because they want only him.

Guido and Maria's relationship falls apart due to a misunderstanding. Even Grandpa Libero is furious with the boy, unable to understand that it's not actually his fault. Guido then decides to make a video to explain everything. Given all hope of getting Maria back, Guido requests an immediate transfer to Milan and says goodbye to Marcello and Carlotta outside the local health authority. On the way to church, Maria realizes she wants Guido and runs to the station...

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.