When beautiful-but-vapid model wannabe Deb dies in a car accident, she is accidentally relegated to the body of the recently deceased Jane Bingum. Now, by a twist of fate and a bolt of divine intervention, Deb must come to terms with inhabiting Jane's curvier frame in the ultimate showdown between brains and beauty.

Jane's journey continues in season two when, at the close of last season, Deb was ready to let go of her past and embrace her new life as Jane. But faced with a new love triangle and the uncertainty of her career, Jane must, once-again, chart out a new future for herself.

Being her former lover's best friend in her new life is not as easy as it seems when in season 3 Jane promises to be the best man at his wedding. She also has many complicated cases to work on, including defending a man who held her up at gunpoint, representing a high-school lesbian couple who are not permitted to attend prom and getting justice for a bride-to-be who was trampled at a bridal super sale.

Season four begins with Jane and Owen enjoying a Roman Holiday in Italy while back at home, the firm is going all sorts of cray under Kim’s leadership. Teri is sent to bring Jane home to take on murder case and Grayson comes to terms with his new feelings for Jane. Fred tries to moves on with a new girlfriend, leading Stacy to seek out a relationship guru for love advice.

The fifth series picks up with Jane frantically searching for her missing fiancé Owen, who disappeared after witnessing her kiss Grayson moments before their wedding. While both Jane and Owen nurse their broken hearts, Jane’s friends and co-workers also are confronted with their own life dilemmas. Kim goes public with her pregnancy at the firm as Grayson continues to struggle with his feelings for Jane. Meanwhile, Stacy is left contemplating the future of her business, The Pakery.

Jane is forced to finally tell the truth to Grayson, but his reaction leaves her more lost than ever. Meanwhile Owen gets a visit from his estranged brother, Charlie, that puts his personal life and the firm at risk. As Jane buries herself in work once again to hide from the problems in her life, she discovers her new pro bono case has high stakes with the U.S. government. With Kim on maternity leave, a new lawyer, Belinda joins the firm and gives Jane a run for her money.