Recent graduates of a secluded U.S. Air Force base must protect a gene-editing bioweapon from the Russian military—who are desperate to seize the deadly viral agent at any cost.

An airliner filled with 800 passengers is forced to fly fast and low, above farmlands, suburbs and skyscraper-packed cities or the tons of explosives aboard will detonate. When an elite unit of US Air Force fighter jets is sent to provide escort, they find themselves facing a squadron of unidentifiable warplanes which ignites a deadly air battle that threatens to destroy all life above and below.

During a new age of tensions between America and Russia, an assassination attempt is made on the Russian president while visiting the White House. An enraged Russia scrambles jets over the Atlantic, forcing the U.S. to fill the sky with its own fighters trying to stop the high-tech SU-57 squadrons before they ravage Washington, D.C.