Grisly strangulations in London alert Nayland Smith of Scotland Yard to the possibility that fiendish Fu Manchu may not after all be dead, even though Smith witnessed his execution. A killer spray made from Tibetan berries seems to be involved and clues keep leading back to the Thames.

This time Fu Manchu and his army of henchmen are kidnaping the daughters of prominent scientists and taking them to his remote island headquarters. Instead of asking for ransom, Fu demands that the fathers help him to build a death ray, which he intends to use to take over the world. But Fu's archenemy, Nayland Smith of Scotland Yard, is determined not to let that happen.

Fu Manchu abducts a missionary doctor and forces him to surgically turn one of his hypnotized dacoits into a murderous doppelgänger of his arch-nemesis Inspector Nayland Smith of Scotland Yard as, part of a plan to become leader of the World's criminals

In his remote jungle hideout, the evil Fu Manchu and his sadistic daughter Lin Tang have discovered a deadly venom that affects only men. Using mind control Fu Manchu recruits six women to become carriers of the 'kiss of death' targeting key people of political influence. This will prevent them from interfering with his own ambition to spread his venomous death around the World's major cities in a plan to gain World domination.

The evil mastermind Fu Manchu plots his latest scheme to basically freeze over the Earth's oceans with his diabolical new device. Opposing him is his arch-nemesis, Interpol's very British Nayland Smith.