A serial killer terrorises the city of Kolkata and leaves behind verses of Bengali poetry. The police seek the help of a retired officer to unravel the case and find the perpetrator.

Dwitiyo Purush is a sequel of Baishe Srabon were Prosenjit Chatterjee dies at the end. In this film we will see Parambrata chattopadhyay as a police inspector who follows the path that Prasenjit Chatterjee showed him in Baishe Srabon to fight with criminals in various regions of kolkata.