In the land of Oz, ostracized and misunderstood green-skinned Elphaba is forced to share a room with the popular aristocrat Glinda at Shiz University, and the two's unlikely friendship is tested as they begin to fulfill their respective destinies as Glinda the Good and the Wicked Witch of the West.

As an angry mob rises against the Wicked Witch, Glinda and Elphaba will need to come together one final time. With their singular friendship now the fulcrum of their futures, they will need to truly see each other, with honesty and empathy, if they are to change themselves, and all of Oz, for good.