Paula, the ape woman, has survived the ending of CAPTIVE WILD WOMAN and is running around a creepy old sanitarium run by the kindly Dr. Fletcher, reverting to her true gorilla form every once in a while to kill somebody.

An insane scientist doing experimentation in glandular research becomes obsessed with transforming a female gorilla into a human...even though it costs human life.

Once again Paula the ape woman is brought back to life, this time by a mad doctor and his disfigured assistant, who also kidnaps a nurse in order to have a female blood donor.

After a young woman is coerced into prostitution and her brother framed for murder by an organized crime syndicate, retribution in the form of an ape visits the mobsters.