The story is about four beautiful half-sisters - Isabella, Courtney, Stephanie and Patricia - who have problems in their personal life. Isabella has issues with commitment, Stephanie is having problems with her husband Richard, Courtney's boyfriend Patrick becomes a Born again Christian and Patricia publishes her new sex book much to the dismay of her husband who's having trouble with their relationship as a couple.

The story of Desperadas 2 is about four half-sisters - Isabella, Patricia, Stephanie, and Courtney - who have another big problems in their life. They also found out that they have another half-sister, Lugaluda.