In 1923 the scientist Von Dracula invented Vampisol, a drink that allowed vampires to live in the sun. La Capa Nostra and the European Vampire Group confront each other in Havana to control the Vampisol, but Pepe, Von Dracula's nephew, sang the Vampisol formula for free on Radio Vampiro Internacional. Now Pepe must face the Nazi vampires, who use the most powerful Vampisol: El Vampiyaba.

Professor Von Dracula, a vampire scientist, leaves Transylvania for Cuba, where he invents "Vampisol," a potion that allows vampires to survive in sunlight. When the professor announces his intention to donate the formula free-of-charge to vampires all over the world, the Vampire Mafia from Chicago and the European Group of Vampires from Düsseldorf try to muscle in and steal the formula. The action escalates crazily as an assortment of bad guys, police, vampires and other monsters, and our hero and his girlfriend are all caught up in the chase.