Samuel, who has three daughters, loses his wife at an early stage of his married life. He faces several hardships in dealing with the plight of each daughter.

Achanurangaatha Veedu (2006) told the story of a father's suffering as his under-aged daughter Lisamma is kidnapped and is forced into a sex racket. In Lisammayude Veedu, the young girl Lisamma (Meera Jasmine) has grown up and seems to have adjusted to her past. She runs a telephone booth and looks after her two sisters and her father who has lost his mental balance after seeing his daughter suffer.