The Duke Boys and company travel to Hollywood to sell some musical recordings in order to raise money to build a new hospital in Hazzard County. However, when their recordings and money are stolen, they wind up on the run from mysterious hitmen, sleazy record producers, Russian gangsters, and vicious loan sharks.

Mama Josephine Max wants to build a theme park in Hazzard, right on the Duke family farm! To stop her, Bo and Luke have to win a cross-country moonshine race. Because that's how things get settled in Hazzard.