A nerdy high school super whiz experiments with a chemical which will transform his guinea pig "Mr. Mumps" from a gentle pet into a ravenous monster. In a fit of rage against his tormentors at the high school, Vernon Potts goes on a killing spree, eliminating all of those who ever picked on him - the Gym Coach, the School Jock, The Creepy Janitor & his hated teacher, Ms. Grindstaff.

A few years ago, a mysterious serial-killer caused panic on Crippen High School. The killer was never caught. A movie company, Cosmic Pictures, has decided to make a feature movie about these events - on location, at the now abandoned school. Since members of cast and crew disappear without a trace, it seems as if history is repeating itself...