A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.

Happy couple Jason and Alexandra lose their sail yacht in a storm and are grateful to get picked up by Captain Jim Bigelow's commercial carrier. Suspicious about the ship's doctor and realizing the ship is improbably empty and the radio not broken as the crew claims, Jason starts snooping around. Bodies on meat-hooks, genetic experimentation and giant spiders are what he finds.