Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.

A twisted teenage prostitute and an equally deranged vicious killer manage to escape from the pen and embark on a non-stop orgy of violence and debauchery, all while hoping to make it across the border into Mexico in order to seek refuge with the mysterious Sister Gomez.