After losing their academic posts at a prestigious university, a team of parapsychologists goes into business as proton-pack-toting "ghostbusters" who exterminate ghouls, hobgoblins and supernatural pests of all stripes. An ad campaign pays off when a knockout cellist hires the squad to purge her swanky digs of demons that appear to be living in her refrigerator.

The discovery of a massive river of ectoplasm and a resurgence of spectral activity allows the staff of Ghostbusters to revive the business.

When single mom Callie and her two kids Trevor and Phoebe arrive in a small Oklahoma town, they begin to discover their connection to the original Ghostbusters and the secret legacy their grandfather left behind.

When the discovery of an ancient artifact unleashes an evil force, Ghostbusters new and old must join forces to protect their home and save the world from a second Ice Age.