An American nurse living and working in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim.

A young woman encounters a malevolent supernatural force while searching for her missing sister in Tokyo, a mean high school prank goes horribly wrong, and strange things begin happening in a Chicago apartment building.

Jake Kimble, the sole survivor of the Chicago massacre, is killed while in solitary confinement. His doctor begins investigating the claims he made about a long-haired woman in white, as a mysterious Japanese woman arrives at his old apartment building to help them get rid of the curse.