Akira is just another normal kid in modern-day Tokyo, until an old friend of his, Ryo, shows up and turns his world upside down. Akira learns that there is an upcoming war of demons on humanity and he has just been enlisted for a major tour of duty. But the only way to fight a demon is with their power, so Akira and Ryo risk a dangerous ceremony in an attempt to create humanity's only hope: the powerful Devilman.

Akira Fudo (aka Devil Man) fights more demons trying to kill him. The strongest enemy sent from the demon's world is Silen, the demon bird.

Fear runs rampant throughout Tokyo with the revelation that demons in fact exist amongst us. Paranoia and the darker side of humanity boils onto the streets as people turn on one another, suspecting that anyone could in fact be a demon hiding in human clothing. Amidst the growing tensions, tragedy strikes Akira causing his mind to snap, retreating into his subconscious, allowing his Devilish alter-ego Amon to break free from Akira's cage of flesh and wreak havoc on both human and demons alike.