Yuta Okkotsu is a nervous high school student who is suffering from a serious problem—his childhood friend Rika has turned into a curse and won't leave him alone. Since Rika is no ordinary curse, his plight is noticed by Satoru Gojo, a teacher at Jujutsu High, a school where fledgling exorcists learn how to combat curses. Gojo convinces Yuta to enroll, but can he learn enough in time to confront the curse that haunts him?

Pursued by a religious cult and other curse users, former friends Satoru Gojo and Suguru Geto are the only sorcerers capable of carrying the difficult task of protecting Riko Amanai, a student who has been designated to be sacrificed as the Star Plasma Vessel, until she can fulfill her duty.