Four inseparable friends try to face their midlife crisis with daytrips and pranks at the expense of their families and the people around them.

The four old friends meet on the grave of the fifth of them, Perozzi, who died at the end of the first episode. Time has passed but they are still up for adventures and cruel jokes, and while they recall the one they created together with the late friend, new ones are on their way, starting right there at the cemetery.

This time the "amici" (friends) are just four: Necchi, Meandri, Mascetti and Sassaroli. Nevertheless they are older they still love to spend their time mainly organizing irresistible jokes to everyone in every kind of situation. Mascetti is hospitalized in a geriatric clinic. Of course the place become immediately the main stage for all their jokes. After some jokes they decided to place an ultimate incredible and farcical joke to the clinic guests.

Jacopo, Duccio, Cecco, Manfredo and Filippo are five friends who live in Florence of the fifteenth century, during a plague epidemic.