A young woman from the Midwest gets more than she bargained for when she moves to New York to become a writer and ends up as the assistant to the tyrannical, larger-than-life editor-in-chief of a major fashion magazine.

Miranda Priestly navigates her career amid the decline of traditional magazine publishing. She faces off against Emily Charlton, her one-time assistant, now a high-powered executive for a luxury group, with advertising dollars that Priestly desperately needs.