Years after the end of the original series, David Banner continues his wandering search for a cure for the condition that turns him into the Hulk. He reunites with former colleague Don Blake, unaware of his mystical connection to Thor. When a criminal organization threatens their lives, Banner is forced to unleash the Hulk once again, marking the character’s return after the series finale.

In his final attempt to free himself from the curse of the Hulk, Dr. David Banner becomes involved in a dangerous international espionage mission that may finally lead to a cure. As forces close in and the stakes rise, Banner faces an ultimate sacrifice, bringing his tragic journey to a definitive and emotional conclusion.

An accidental overdose of gamma radiation causes a mutation in scientist David Banner's DNA: now whenever he becomes angry, he metamorphoses into a seven-foot-tall, 330-pound, mindless muscular green creature.

Falsely accused of assault, Dr. David Banner is arrested and placed on trial, facing the possibility of a long prison sentence. Blind attorney Matt Murdock takes on his defence, while secretly operating as the vigilante Daredevil. As the courtroom battle unfolds, Banner’s struggle to control the Hulk leads to a dangerous confrontation with criminal mastermind Wilson Fisk.

In one of the saga's most emotional stories, David Banner travels to Hawaii to find Dr. Caroline Fields, a psychiatrist who has developed a hypnotherapy technique that could cure him. Discovering they share the burden of an incurable condition—Caroline suffers from a terminal illness—the two fall in love and marry, offering Banner a glimpse of happiness. However, tragedy looms when Jack McGee's relentless pursuit and a devastating hurricane threaten their brief moment of peace.

Continuing his solitary flight, David Banner arrives in a small town where he saves the life of a young heiress, the target of a deadly conspiracy orchestrated by her stepmother and a corrupt physician. While working undercover to protect the girl and dismantle the plot, Banner must struggle to contain the beast within, especially when the arrival of reporter Jack McGee threatens to expose his secret to the world.