Visionary Miskatonic University student Crawford Tillinghast follows in his late father's footsteps and becomes obsessed with completing work on the Resonator, an inter-dimensional device that opens doorways to other worlds.

The malevolent inter-dimensional machine is still channeling monsters and blowing minds, but this time things get even more complicated with the arrival of mad med student Herbert West and his dreaded reagent!

Herbert West is totally out of control on campus, sticking his glowing green reagent into every corpse he can find!