Before the Kalyug begins, Lord Krishna hands over an anklet that holds the answer to all of world’s miseries. Years later a doctor finds himself in the thick of things when the pursuit for the anklet carries on. A doctor with a curious mind, Karthikeya, aka Karthik, believes in pursuing the truth. The quest leads Karthik to discover the power of the ancient Indian belief system and the essence of Krishna.

Nikhil Siddharth and Swathi Reddy are back once again onscreen with Karthikeya. The mystery of the Subramanian Swamy temple which has remained closed for years is the crux of the movie. Local people in the village are curious why the temple has been locked up for years? The lead protagonists take the initiative to solve the mystery.

The storyline of 'Karthikeya 3' will revolve around the mysteries of Lord Khrishna and the city of Dwarka.